Professional Bio

Education

  • Postdoctoral research, Virology, University of Colorado Health Sciences Center-Denver
    With Lewis I. Pizer (Department of Microbiology & Immunology). Regulation of Herpes simplex virus glycoprotein D (gD) gene by the ICP4 (Vmw175, IE3) protein
  • Postdoctoral research, Molecular Biology, University of Colorado Health Sciences Center-Denver
    With John R. Sadler (Department of Biophysics & Genetics). Escherichia coli lactose repressor-operator interaction.
  • Ph.D., Biochemistry, University College-London
    Advisor Patricia H. Clarke, F.R.S., Phenylacetamidases in Pseudomonas aeruginosa
  • M.Sc., Microbiology, Yale University
    Advisor  P.T. Magee. Threonine Deaminase of Saccharomyces cerevisiae
  • B.A., Biology, Oberlin College 

Professional Memberships

  • American Society for Microbiology
  • American Association for the Advancement of Science
  • Genetics Society of America
  • National Association of Advisors for the Health Professions
  • Council for Undergraduate Research
  • Alpha Epsilon Delta (National Health Preprofessional Honor Society)

Research & Scholarship

Research Interests
Mechanisms of regulation of gene expression in prokaryotes and eukaryotes, particularly protein-DNA interactions controlling initiation of transcription.

Presentations

Betz, J.L., Hoffman, M.G., Nordick, K.M., Campsteijn, C., Cohen, A., Jansen, P., Logie, C., Stunnenberg, H. and Jaehning, J.A. (Nov., 2006). Interactions of the Paf1 complex: Paf1C is required for association of cleavage and poly(A) factors with RNA polymerase II. The 17th Annual Molecular biology Retreat (UCDHSC), Winter Park, CO. (poster).

Betz, J.L., Hoffman, M.G., Nordick, K.M., Campsteijn, C., Cohen, A., Jansen, P., Logie, C., Stunnenberg, H. and Jaehning, J.A. (July, 2006). Interactions of the Paf1 complex: Paf1C is required for association of cleavage and poly(A) factors with RNA polymerase II. Yeast Genetics and Molecular Biology Meeting, Princeton, NJ. (poster).

Betz, J.L., Hoffman, M.G., Nordick, K.M., Penheiter, K.L. and Jaehning, J.A. (Aug., 2005). The yeast Paf1 complex is required for association of cleavage and poly(A) factors with pol II. Mechanisms of Eukaryotic Transcription. Cold Spring Harbor Laboratory, NY. (poster).

Betz, J.L., Nguyen, B.T. and Jaehning, J.A. (Nov., 2004). Over-expression of Cln2 or Cln3 suppresses loss of the Paf1/RNA polymerase II complex. The 15th Annual Molecular biology Retreat (UCHSC), Winter Park, CO. (poster).

Betz, J.L., Nguyen, B.T. and Jaehning, J.A. (July, 2004). Over-expression of Cln2 or Cln3 suppresses loss of the Paf1/RNA polymerase II complex. Yeast Genetics and Molecular Biology Meeting, Seattle, WA. (poster).

Betz, J.L. (March, 2004). Adventures in Genetics: research with model systems. Regis University (invited seminar as Regis College Faculty Lecturer of the Year, 2003).

Betz, J.L., Nguyen, B.T. and Jaehning, J.A. (Nov., 2003). Suppressors of pleiotropic phenotypes of mutants of the Paf1/RNA polymerase II complex. The 14th Annual Molecular biology Retreat (UCHSC), Estes Park, CO. (poster).

Betz, J.L., Nguyen, B.T. and Jaehning, J.A. (Aug., 2003). Suppressors of pleiotropic phenotypes of mutants of the Paf1/RNA polymerase II complex. Conference on Mechanisms of Eukaryotic Transcription. Cold Spring Harbor Laboratory, NY. (poster).

Betz, J.L., Nguyen, B.T. and Jaehning, J.A. (Nov., 2002). High copy suppressors of Paf1 complex mutants. UCHSC Molecular Biology retreat, Winter Park, CO. (poster).

Betz, J.L. Porter, S.E., Washburn, T.M. and Jaehning, J.A. (Aug., 2002) Suppression of pleiotropic phenotypes of paf1 by over-expresion of Swi4, Mbp1 and Rnr1 confirms the role of the Paf1/RNA polymerase II complex in cell cycle regulation. Yeast Genetics and Molecular Biology Meeting, Madison, WI. (poster).

Betz, J.L., Chang, M., Washburn, T., Porter, S. and Jaehning, J.A. (Nov., 2001). Expanded functional role of the yeast Paf1p/RNA polymerase II complex deduced from phenotypic analysis. UCHSC Molecular Biology retreat, Estes Park, CO. (poster).

Betz, J.L., Chang, M., Washburn, T., Porter, S. and Jaehning, J. (Aug., 2001). Genetic analysis of the function of the Paf1p/RNA polymerase II complex. Conference on Mechanisms of Eukaryotic Transcription. Cold Spring Harbor Laboratory, NY. (poster).

Betz, J.L., Chang, M., Washburn, T., Porter, S. and Jaehning, J. (Nov., 2000). Genetic analysis of the role of the Paf1p/RNA polymerase II complex. UCHSC Molecular Biology Retreat, Estes Park, CO. (poster).

Betz, J.L. (June, 2001). Genetic analysis of the role of the Paf1p/RNA polymerase II complex. Dept. Biochemistry and Molecular Genetics, UCHSC. (seminar).

Betz, J.L., Goyette, K., Chang, M. and Jaehning, J.A. (July, 2000). Genetic analysis of the role of the Paf1p/RNA polymerase II complex in the Pkc1p signaling pathway. Yeast Genetics and Molecular Biology Meeting, Seattle, WA. (poster).

Betz, J.L., Chang, M., Goyette, K., Porter, S., Mueller, C. and Jaehning, J.A. (June, 2000). The yeast Paf1p/RNA polymerase II complex mediates protein kinase C signaling and is important for expression of cell cycle regulated genes. FASEB Summer Research Conference on Transcriptional regulation during cell growth, differentiation and development, Snowmass, CO. (poster).

Publications

Nordick, K., Hoffman, M.G., Betz, J.L. and Jaehning, J.A. (2008). Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II. Eukaryotic Cell 7: 1158-1167 (epub 2008 May 9).

Betz, J.L., Chang, M., Washburn, T.M., Porter, S.E., Mueller, C.L. and Jaehning, J.A. (2002). Phenotypic analysis of Paf1/ RNA polymerase II complex mutations reveals connections to cell cycle regulation, protein synthesis, and lipid and nucleic acid metabolism. Mol. Gen. Genomics. 268: 272-285.

Awards & Recognition

Awards

  • Regis College Faculty Lecturer of the year, presentation “Adventures in Genetics: Research with Model Systems”, 2003
  • National Institutes of Health Postdoctoral Fellow, 1974-1976
  • National Science Foundation Predoctoral Fellow, 1970-1972

Recent Extramural Funding

NIH AREA grant R15 AI 32665 "Gene regulation by Varicella zoster virus VP140 protein", Joan Betz, principal investigator (7-1-92 to 6-30-95), $75,000 direct costs; extended without additional funding to 6-30-96.

NSF DUE 9551978 "Fluorescent spectrometry in the undergraduate program at Regis University", Surendra Mahapatro, principal investigator; Joan Betz, co-principal investigator (7-1-95 to 6-30-97), $13,306 costs (matched by Regis).                        .

NIH AREA grant R15 DK/OD 52577 "Transcriptional competence of the PML-RAR fusion receptor", Joan Betz, principal investigator (6-1-97 to 5-31-00), $75,000 direct costs; extended without additional funding to 5-31-01.

NSF DUE 952711 "Integrated neuroscience laboratories", Gene Delay, principal investigator; Joan Betz, Surendra Mahapatro, and Clifford Barnes, co-principal investigators (6-1-00 to 5-31-02), $25,000 direct costs (matched by Regis). 

NIH RO1 grant GM38101 "Mechanisms of yeast transcription". Judith Jaehning, principal investigator (12-01-00 to 11-30-04) $800,000 total direct costs. Joan Betz, co-PI (summer salary).

NIH R15 GM076099 “Subunit interaction of components of the yeast Paf1 complex”. Joan Betz, principal investigator (1-1-06 to 12-31-08). $150,000 total direct costs (about $30,000 indirect);  extended without additional funding to 12-31-10.

Recent and Current Intramural Funding

Regis SPARC (Sponsored Projects Academic Research Council) grant: "Genetic analysis of transcriptional regulation by the yeast Paf1/RNA polymerase II complex", Joan Betz, principal investigator (5-1-01 o 4-31-02) $3000 direct costs.

Regis SPARC grant: “Subunit interaction of components of the yeast Paf1 complex”. Joan Betz, principal investigator (5-1-05 to 4-30-06) $2642 direct costs.

Regis SPARC grants to undergraduate students: six different research students have each received up to the $500 (maximum) annual awards to support supplies for research and travel to scientific conferences (Cheryl Dunne, Bao T. Nguyen (2), Tom Deem (2), Brian Couch, Donovan Rigirozzi, Randal Davis). These students presented the results of their research at the annual Regis Student Research Symposia, and in three cases, presented at the West Coast Biological Sciences Undergraduate Research Symposia.

Regis Faculty Development Committee grants:

Travel grants:  since 1990, have received nearly annual awards of $800 to $1200 (maximum permitted) towards travel to a professional conference.

Small grants:  since 1990, have received nearly annual awards of $300 (maximum permitted) for purchase of special reagents, small equipment, prepared microscope slides, repair of equipment and other items to improve teaching and research.