Research & Scholarship
Re-iterated use of a common toolbox of molecular interactions and gene expressions are known to play important roles in patterning primordial tissues in multiple organisms from the nematode to humans. Dr. Melvin is especially interested in using easily manipulated model organisms to undersand complex development processes that are relevant to human disease. Her most recent research has been focused on using the zebrafish, Danio rario
, to identify genes important in craniofacial development utilizing a reverse-genetic approach.
Senkus Melvin, V., Feng, W., Hernandez, A., Artinger, K.B., Williams, T. (2013) A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Dev. Dyn. 242:817-831
Senkus Melvin, V., Harrell, C, Adelman, J.S., Kraus, W.L., Churchill, M., and Edwards, D.P. (2004) The role of the C-terminal extension (CTE) of the estrogen receptor a and b DNA binding domain in DNA binding and interaction with HMGB. J. Biol. Chem. 279:14763-14771.
Senkus Melvin, V., and Edwards, D.P. (2002) The carboxyl-terminal extension (CTE) of the nuclear hormone receptor DNA binding domain determines interactions and functional response to the HMGB-1/-2 coregulatory proteins. J. Biol. Chem. 277:25115-25124.
Senkus Melvin, V., and Edwards, D.P. (1999) Coregulatory proteins in steroid hormone receptor action: The role of chromatin high mobility group proteins, HMG-1 and -2. Steroids. 64: 576-586.
Boonyaratanakornkit, V.*, Melvin, V.*, Prendergast, P.*, Altmann, M., Ronfani, L., Bianchi, M.E., Taraseviciene, L., Nordeen, S.K., Allegretto, E.A., and Edwards, D.P. (1998) High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells. Mol. Cell. Biol. 18: 4471-4487. *These authors contributed equally.
Senkus Melvin V., Taiyab, A., Reid, B.S. and Williams, T. (2011) Epithelial-mesenchymal signaling interactions coordinating limb and face patterning. Mouse Molecular Genetics, Wellcome Trust Conference Center, Hinxton, Cambridge, UK.
Senkus Melvin V., Feng, W., Hernandex, A., Artinger, K.B., and Williams, T. (2009) Mouse and Zebrafish Models to Screen Genes Involved in Craniofacial Development. Gordon Research Conference on Craniofacial Biology, Il Ciocco, Italy.
Senkus Melvin, V., and Edwards, D.P. (2001) The role of the C-terminal extension from the steroid receptor DNA binding domain in DNA binding affinity and binding site preference. The Endocrine Society 83rd Annual Meeting, Denver, CO. **Oral Presentation
Senkus Melvin, V., and Edwards, D.P. (1999) HMG-1/-2 selectively influences DNA binding of steroid hormone receptors by functionally substituting for the minor groove DNA interface intrinsic to other nuclear receptors. The Endocrine Society 81st Annual Meeting, San Diego, CA. **Oral Presentation
Senkus Melvin, V., and Edwards, D.P. (1999) HMG-1/-2 selectively influences DNA binding of steroid hormone receptors by functionally substituting for the minor groove DNA interface intrinsic to other nuclear receptors. Gordon Research Conference on Hormone Action, Kimball Union Academy, Meriden, NH.