Professional Bio

Education

  • Ph.D., 2003, University of California, Berkeley
  • B.S., 1998, St. Cloud State University, Minnesota

Professional Memberships

  • Reviewer for European Journal of Medicinal Chemistry, 2012
  • Session Chair at Gordon Research Conference in Medicinal Chemistry, Late Breaking Topics Session 2007
  • American Chemical Society National, Organic and Medicinal Chemistry Divisions, 1997-present

Research & Scholarship

Research Experience

  • Synthetic organic chemistry
  • Asymmetric catalysis
  • C-H bond activation
  • Natural product synthesis
  • Medicinal chemistry

PATENTS AND PUBLICATIONS

Ren, L.; Ahrendt, K.A.; Grina, J.; Laird, E.R.; Buckmelter, A.J.; Hansen, J.D.; Newhouse, B.; Moreno, D.; Wenglowsky, S.; Dinkel, V.; Gloor, S.L.; Hastings, G.; Rana, S.; Rasor, K.; Risom, T.; Sturgis, H.L.; Voegtli, W.C.; Mathieu, S. The Discovery of Potent and Selective Pyridopyrimidin-7-one Based Inhibitors of B-RafV600E Kinase. Bioorg. Med. Chem. Lett. 2012, 22, 3387-3391.

Wenglowsky, S.; Moreno, D.; Rudolph, J.; Ran, Y.; Ahrendt, K.A.; Arrigo, A.; Colson, B.; Gloor, S.L.; Hastings, G. Pyrazolopyridine Inhibitors of B-RafV600E. Part 3: An Increase in Aqueous Solubility via the Disruption of Crystal Packing. Bioorg. Med. Chem. Lett. 2012, 22, 912-915.

Wenglowsky, S.; Ahrendt, K.A.; Buckmelter, A.J.; Feng, B.; Gloor, S.L.; Gradl, S.; Grina, J.; Hansen, J.D.; Laird, E.R.; Lunghofer, P.; Mathieu, S.; Moreno, D.; Newhouse, B.; Ren, L.; Risom, T.; Rudolph, J.; Seo, J.;Sturgis, H.L.; Voegtli, W.C.; Wen, Z. Pyrazolopyridine Inhibitors of B-RafV600E. Part 2: Structure- Activity Relationships. Bioorg. Med. Chem. Lett. 2011, 21, 5533-5537.

Wenglowsky, S.; Ren, L.; Ahrendt, K.A.; Laird, E.R.; Aliagas, I.; Alicke, B.; Buckmelter, A.J.; Choo, E. F.;Dinkel, V.; Feng, B.; Gloor, S.L.; Gould, S. E.; Gross, S.; Gunzner-Toste, J.; Hansen, J.D.; Hatzivassiliou,G.; Liu, B.; Malesky, K.; Mathieu, S.; Newhouse, B.; Raddatz, N.J.; Ran, Y.; Rana, S.; Randolph, N.; Risom,T.; Rudolph, J.; Savage, S.; Selby, L.T.; Shrag, M.; Song, K.; Sturgis, H.L.; Voegtli, W.C.; Wen, Z.; Willis,B.S.; Woessner, R.D.; Wu, W.-I.; Young, W.B.; Grina, J. Pyrazolopyridine Inhibitors of B-RafV600E. :Part 1:The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors. ACS Med. Chem. Lett. 2011,2, 342-347.

Ahrendt, K. A.; Buckmelter, A. J.; Grina, J.; Hansen, J. D.; Laird, E. R.; Newhouse, B.; Ren, L.; Wenglowsky, S. M.; Feng, B.; Malesky, K.; Mathieu, S.; Rudolph, J.; Wen, Z.; Young, W. B.; Moreno, D.A. N-(6-Aminopyridin-3-yl)-3-(Sulfonamide)Benzamide Derivatives as B-Raf Inhibitors for the Treatment of Cancer and Their Preparation. PCT Int. Appl. (2009) WO 2009111280.

Ahrendt, K. A.; Buckmelter, A. J..; De Meese, J.; Grina, J.; Hansen, J. D.; Laird, E. R.; Lunghofer, P.; Moreno, D.; Newhouse, B.; Ren, L.; Seo, J.; Tian, H.; Wenglowsky, S. M.; Feng, B.; Gunzner, J.; Malesky,K.; Mathieu, S.; Rudolph, J.; Wen, Z.; Young, W. B. N-Pyrazolo[3,4-]pyridinyl Benzamide Derivatives as Raf Inhibitors and Their Preparation, Pharmaceutical Compositions and Use in the Treatment of Diseases. PCT Int. Appl. (2009) WO 2009111279.

Kateri Ann Ahrendt, Ahrendt, K. A.; Buckmelter, A. J.; Grina, J.; Hansen, J. D.; Laird, E. R.; Moreno, D.; Newhouse, B.; Ren, L.;Wenglowsky, S. M.; Feng, B.; Gunzner, J.; Malesky, K.; Mathieu, S.; Rudolph, J.; Wen, Z.; Young, W. B.N-Pyrrolo[2,3-]pyridinyl Benzamide Derivatives as Raf Inhibitors and Their Preparation, PharmaceuticalCompositions and Use in the Treatment of Disease. PCT Int. Appl. (2009) WO 2009111278.

Ahrendt, K. A.; Buckmelter, A. J.; Grina, J.; Hansen, J. D.; Laird, E. R.; Newhouse, B.; Ren, L.;Wenglowsky, S. M.; Feng, B.; Malesky, K.; Mathieu, S.; Rudolph, J.; Wen, Z.; Young, W. B.; Moreno, D.A. Imidazo[4,5-]pyridine Derivatives as Raf Inhibitors and Their Preparation and use in the Treatment of Diseases. PCT Int. Appl. (2009) WO 2009111277.

Ahrendt, K. A.; Delisle, R. K.; Hans, J.; Lyssikatos, J. P.; Robinson, J. E.; Wallace, E. M.; Zhao, Q. Preparation of Difluorophenylcarbonylphenyldihydrothiadiazole Derivatives for Use as Mitotic Kinesin Inhibitors. PCT Int. Appl. (2008) WO 2008042928.

Thalji, R. K.; Ahrendt, K. A.; Bergman, R. G.; Ellman, J. A. Annulation of Aromatic Imines via Directed CHBond Activation. J. Org. Chem. 2005, 70, 6775.

Ahrendt, K. A; Williams, R. M. A Concise Asymmetric Synthesis of the ADE Fragment of Nakadomarin A.Org. Lett. 2004, 6, 4539.

Ahrendt, K. A.; Bergman, R. G.; Ellman, J. E. Synthesis of a Tricyclic Mescaline Analogue by Catalytic CHBond Activation. Org. Lett. 2003, 5, 1301.

Ahrendt, K. A.; Olsen, J. A.; Wakao, M.; Trias, J.; Ellman, J. A. Identification of Potent and Broad Spectrum Antibiotics from SAR Studies of a Synthetic Vancomycin Analogue. Bioorg. Med. Chem. Lett. 2003, 13, 1683.

Thalji, R. K.; Ahrendt, K. A.; Bergman, R. G.; Ellman, J. A. Annulation of Aromatic Imines via Directed CH Activation with Wilkinson's Catalyst. J. Am. Chem. Soc. 2001, 123, 9692.

MacMillan, D. W. C.; Ahrendt, K. A. Chemical Synthesis Using Nonmetallic Organic Catalyst Compositions. PCT Int. Appl. (2001) WO 2001053241.

MacMillan, D. W. C.; Ahrendt, K. A. Preparation of Imidazolidinone Acid Salts as Reaction Catalysts. PCT Int. Appl. (2001) WO 2001053269.

Ahrendt, K. A.; Borths, C. J.; MacMillan, D. W. C. New Strategies for Organic Catalysis: The First Highly Enantioselective Organocatalytic Diels-Alder Reaction. J. Am. Chem. Soc. 2000, 122, 4243.

Fischer, P. J.; Ahrendt, K. A.; Young, V. G., Jr.; Ellis, J. E. Trityltitanium Complexes. X-ray Structural Characterization of [Ti(CO)4{5-C(4-C6H4R)3}]- (R = H, OCH3). Organometallics 1998, 17, 13.

Awards & Recognition

Professional Activities, Awards and Affiliations

  • Reviewer for European Journal of Medicinal Chemistry, 2012
  • Session Chair at Gordon Research Conference in Medicinal Chemistry, 2007
  • National Institutes of Health (NIH) Postdoctoral Research Fellowship, 2003-2005
  • Outstanding Graduate Student Instructor Award, 1999-2000
  • National Science Foundation Summer Undergraduate Research Fellow, 1997
  • National Science Foundation Summer Undergraduate Research Fellow, 1996
  • American Chemical Society National, Organic and Medicinal Chemistry Divisions, 1997-present