Research & Scholarship
Research Interests
- Generation of new organic synthesis methodologies
- Synthesis of molecules for validation of novel biological targets
- Utilization of medicinal chemistry principles to modify structures of biologically active molecules as potential drug leads
Courses Taught
- CH210: Principles of Chemistry I
- CH251: Organic Chemistry Laboratory
- CH231: Principles of Chemistry Laboratory
- CH206A: Chemistry for Health-Related Sciences
- CH207A: Chemistry for Health-Related Sciences Laboratory
Publications
“Discovery and SAR of spirochromane Akt inhibitors” Kallan, Nicholas C.; Spencer, Keith L.; Blake, James F.; Xu, Rui; Heizer, Justin; Bencsik, Josef R.; Mitchell, Ian S.; Gloor, Susan L.; Martinson, Matthew; Risom, Tyler; Gross, Stefan D.; Morales, Tony H.; Wu, Wen-I; Vigers, Guy P.A.; Brandhuber, Barbara J.; Skelton, Nicholas J. Bioorg. Med. Chem. Lett. 2011, 21(8), 2410.
“Discovery of Spirocyclic Sulfonamides as Potent AKT Inhibitors with Exquisite Selectivity against PKA” Xu, Rui; Banka, Anna; Blake, James F.; Mitchell, Ian S.; Wallace, Eli M.; Bencsik, Josef R.; Kallan, Nicholas C.; Spencer, Keith L.; Gloor, Susan L.; Martinson, Matthew; Risom, Tyler; Gross, Stefan D.; Morales, Tony H.; Wu, Wen-I; Vigers, Guy P.A.; Brandhuber, Barbara J.; Skelton, Nicholas J. Bioorg. Med. Chem. Lett. 2011, 21(8), 2335.
“Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors” Bencsik, Josef R.; Xiao, Dengming; Blake, James F.; Kallan, Nicholas C.; Mitchell, Ian S.; Spencer, Keith L.; Xu, Rui; Gloor, Susan L.; Martinson, Matthew; Risom, Tyler; Woessner, Richard D.; Dizon, Faith; Wu, Wen-I.; Vigers, Guy P. A.; Brandhuber, Barbara J.; Skelton, Nicholas J.; Prior, Wei Wei; Murray, Lesley J. Bioorg. Med. Chem. Lett. 2010, 20(23), 7037.
“Discovery of pyrrolopyrimidine inhibitors of Akt” Blake, James F.; Kallan, Nicholas C.; Xiao, Dengming; Xu, Rui; Bencsik, Josef R.; Skelton, Nicholas J.; Spencer, Keith L.; Mitchell, Ian S.; Woessner, Richard D.; Gloor, Susan L.; Risom, Tyler; Gross, Stefan D.; Martinson, Matthew; Morales, Tony H.; Vigers, Guy P. A.; Brandhuber, Barbara J. Bioorg. Med. Chem. Lett. 2010, 20(19), 5607.
“Evolution of Akt Inhibitors for the Treatment of Cancer: From an HTS Hit to In Vivo Proof of Concept” Nicholas C. Kallan. University of Colorado Health Sciences Center Structural Biology and Biophysics Program Seminar, February 24, 2010.