Professional Bio

Education

  • Regis University: Assistant Professor of Chemistry (2012-present)
  • Regis University: Adjunct Professor of Chemistry 2011/2012 academic year
  • Array BioPharma, Inc., Discovery Chemistry, Medicinal Chemist  2002-2011
  • Ph.D. University of Colorado, Boulder 2002
  • B.S. Chemistry with Honors, Cum Laude, Davidson College, North Carolina 1996

Research & Scholarship

Research Interests

  • Generation of new organic synthesis methodologies
  • Synthesis of molecules for validation of novel biological targets
  • Utilization of medicinal chemistry principles to modify structures of biologically active molecules as potential drug leads

Courses Taught

  • CH210: Principles of Chemistry I
  • CH251: Organic Chemistry Laboratory
  • CH231: Principles of Chemistry Laboratory
  • CH206A: Chemistry for Health-Related Sciences
  • CH207A: Chemistry for Health-Related Sciences Laboratory

Publications

Discovery and SAR of spirochromane Akt inhibitors” Kallan, Nicholas C.; Spencer, Keith L.; Blake, James F.; Xu, Rui; Heizer, Justin; Bencsik, Josef R.; Mitchell, Ian S.; Gloor, Susan L.; Martinson, Matthew; Risom, Tyler; Gross, Stefan D.; Morales, Tony H.; Wu, Wen-I; Vigers, Guy P.A.; Brandhuber, Barbara J.; Skelton, Nicholas J. Bioorg. Med. Chem. Lett. 2011, 21(8), 2410.

“Discovery of Spirocyclic Sulfonamides as Potent AKT Inhibitors with Exquisite Selectivity against PKA” Xu, Rui; Banka, Anna; Blake, James F.; Mitchell, Ian S.; Wallace, Eli M.; Bencsik, Josef R.; Kallan, Nicholas C.; Spencer, Keith L.; Gloor, Susan L.; Martinson, Matthew; Risom, Tyler; Gross, Stefan D.; Morales, Tony H.; Wu, Wen-I; Vigers, Guy P.A.; Brandhuber, Barbara J.; Skelton, Nicholas J.  Bioorg. Med. Chem. Lett. 2011, 21(8), 2335.

“Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors”  Bencsik, Josef R.; Xiao, Dengming; Blake, James F.; Kallan, Nicholas C.; Mitchell, Ian S.; Spencer, Keith L.; Xu, Rui; Gloor, Susan L.; Martinson, Matthew; Risom, Tyler; Woessner, Richard D.; Dizon, Faith; Wu, Wen-I.; Vigers, Guy P. A.; Brandhuber, Barbara J.; Skelton, Nicholas J.; Prior, Wei Wei; Murray, Lesley J. Bioorg. Med. Chem. Lett. 2010, 20(23), 7037.

“Discovery of pyrrolopyrimidine inhibitors of Akt” Blake, James F.; Kallan, Nicholas C.; Xiao, Dengming; Xu, Rui; Bencsik, Josef R.; Skelton, Nicholas J.; Spencer, Keith L.; Mitchell, Ian S.; Woessner, Richard D.; Gloor, Susan L.; Risom, Tyler; Gross, Stefan D.; Martinson, Matthew; Morales, Tony H.; Vigers, Guy P. A.; Brandhuber, Barbara J. Bioorg. Med. Chem. Lett. 2010, 20(19), 5607.

“Evolution of Akt Inhibitors for the Treatment of Cancer: From an HTS Hit to In Vivo Proof of Concept” Nicholas C. Kallan. University of Colorado Health Sciences Center Structural Biology and Biophysics Program Seminar, February 24, 2010.