Professional Bio

Education

  • Ph.D., Biochemistry, Loyola University Chicago, 2008
  • B.S., Chemistry, Loyola University Chicago, 2003

My teaching style focuses on a discussion based classroom environment where students are actively engaged in the subject matter.  I feel this teaching style made me a natural fit for the Team Based Learning method employed in the School of Pharmacy at Regis University. While in the classroom, I encourage students to look at the underlying assumptions for a particular theory that we may be working on. For example, when teaching protein/ligand binding, I ask students what are the assumptions made by a lock and key mechanism versus an induced fit model? I like to make the students aware that there are several ways of thinking about the same phenomenon.  I encourage openly asking questions in my classroom as well, and I feel that this helps generate dialogue between students and therefore encourages them to critically examine key concepts in the physical sciences.

In addition to teaching in the classroom, I am passionate about teaching and learning in the laboratory.  I feel that the lab is where the frontiers of pharmaceutical sciences are advanced and new knowledge about disease states is obtained.  Furthermore, I believe that the making discoveries in the laboratory help further the Regis University mission of the pursuit of truth.

Before teaching at Regis University, I taught biochemical concepts to first year graduate students and medical students during my postdoctoral fellowship at the University of Colorado School of Medicine.  During my graduate studies in chemistry, I taught general chemistry, organic chemistry, physical chemistry, and biochemistry to both undergraduate and graduate students.

Download Curriculum Vitae

Certifications and Expertise

Professional Memberships

  • American Heart Association (AHA)
  • American Association for the Advancement of Science (AAAS)
  • American Association of Colleges of Pharmacy (AACP)

 

Research and Scholarship

Research Interests

  • Information Theory: How do drugs interact with proteins?
  • Bipolar Disorder: How does lithium serve as an effective therapeutic?
  • Heart Disease: How does a mitochondrial transcription factor mutant lead to cardiomyopathies?
  • Mitochondrial Transcription: Several disease states have altered mitochondrial transcription.
  • Developing Autoimmune Disease Treatments: Autoimmune diseases such as lupus recognize “self” DNA as foreign pathogens. Can we exploit existing DNA binding proteins in the body as therapeutic agents?
  • Testicular Cancer: Can we target the HMGB4/DNA interaction in chemotherapy?
  • Understanding the Sox2/Promoter DNA mechanism: Several development diseases and cancer are associated with malfunctioning Sox2 function. Developing a greater understanding of this interaction at the molecular level could lead to novel therapeutics.

Recent Publications

Malarkey, C.S., Gustafson, C.E., Saifee, J.F., Torres, R.M., Churchill, M.E.A., and Janoff, E.N. (2016) “Mechanism of mitochondrial transcription factor A attenuation of CpG-induced antibody production.” PloS one. 11. E0157157.

Malarkey, CS, Lionetti, C, Deceglie, S, Roberti, M, Churchill, ME, Cantatore, P, Loguercio, P, Polosa, P (2016). The sea urchin mitochondrial transcription factor A binds and bends DNA efficiently despite its unusually short C-terminal tail. Mitochondrion. Apr 14;29:1-6. doi: 10.1016/j.mito.2016.04.004. [Epub ahead of print].

Sánchez-Giraldo, R., Acosta-Reyes, F.J., Malarkey, C.S., Saperas, N., Churchill, M.E.A., and Campos, J.L. (2015) “Two High-Mobility Group Box Domains Act Together to Underwind and Kink DNA.” Acta Crystallographica Section D. 71. 1423-1432.

Das, C., Roy, S., Namshoshi, S., Malarkey, C.S., Jones, D.N.M., Kutateladze, T.G., Churchill, M.E.A., and Tyler, J.K. (2014) “Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.” Proceedings of the National Academy of Sciences. 111, E1072-E1081.

Wysoczynski, C.L., Roemer, S.C., Dostal, V., Barkley, R.M., Churchill, M.E.A., and Malarkey, C.S. (2013) “Reversed-phase Ion-pair Liquid Chromatography Method for Purification of Duplex DNA with Single Base Pair Resolution.” Nucleic Acids Research. 41. e194-e194.

Malarkey, C.S., and Churchill, M.E.A. (2012) “The High Mobility Group Box: the Ultimate Utility Player of a Cell.” Trends in Biochemical Sciences. 37. 553-562.

Malarkey, C.S., Bestwick, M., Kuhlwilm, J., Shadel, G.S., and Churchill, M.E.A. (2012) “Transcriptional Activation by Mitochondrial Transcription Factor A Involves Preferential Distortion of Promoter DNA.” Nucleic Acids Research. 40. 614-62

Recent Presentations

Christopher S. Malarkey. Mitochondrial Transcription Factor A, a Potential DNA “Mop” for the Treatment of Autoimmune Disease. Regis University Department of Biology Seminar Series, Denver, CO. February 2, 2015.

Christopher S. Malarkey, Claire Gustafson, Jessica Saifee, Edward N. Janoff, and Mair E.A. Churchill. Mitochondrial Transcription Factor A Attenuates CpG DNA Mediated Antibody Production From B Cells. University of Colorado School of Medicine Postdoctoral Research Day, Aurora, CO. March 12, 2014.

Christopher Malarkey. Oxidation of Mitochondrial Transcription Factor A Inhibits Mitochondrial Transcription. University of Colorado School of Medicine, Department of Pharmacology Postdoctoral Fellow Seminar Series, Aurora, CO. July 15, 2013.

Christopher S. Malarkey and Mair E.A. Churchill. Deciphering the Role of Reactive Oxygen Species In Mitochondrial DNA Transcription And Protection of the Mitochondrial Genome. University of Colorado School of Medicine Postdoctoral Research Day, Aurora, CO. March 22, 2013.

Christopher Malarkey. Deciphering the Role of Oxidative Stress in Mitochondrial DNA Transcription. University of Colorado School of Medicine, Department of Pharmacology Postdoctoral Fellow Seminar Series, Aurora, CO. August 15, 2012.

Christopher S. Malarkey and Mair E.A. Churchill. Transcriptional Activation by Mitochondrial Transcription Factor A Involves Preferential Distortion of Promoter DNA. University of Colorado School of Medicine Postdoctoral Research Day, Aurora, CO. March 1, 2012.

Christopher Malarkey. Transcriptional Activation by Mitochondrial Transcription Factor A Involves Preferential Distortion of Promoter DNA. University of Colorado School of Medicine, Department of Pharmacology Postdoctoral Fellow Seminar Series, Aurora, CO. October 4, 2011.

Awards & Recognition

Awards

  • 2015-2016 American Association of Colleges of Pharmacy Teacher of the Year Award
  • Outstanding Postdoctoral Fellow Award. University of Colorado School of Medicine, Department of Pharmacology, Aurora, CO, 2013
  • Outstanding Postdoctoral Fellow Award. University of Colorado School of Medicine, Department of Pharmacology, Aurora, CO, 2012

Grants

  • Investigation of the Role of Mitochondrial Transcription Factor A in Heart Disease. Principal Investigator. American Heart Association 13POST16330009 $50,048. Effective Period: 07/01/2013-06/30/2014, awarded 2012.

Community Involvment & Service

Service to Students and University

  • University Research and Scholarship Commitee
  • Assessment Committee for RHCHP and the School of Pharmacy

Service to Profession

  • Journal Reviewer, Nucleic Acids Research and Biochemica et Biophysica Acta Gene Regulatory Mechanisms   

Service to Community

  • Volunteer, The Gathering Place (a women's shelter)