Research & Scholarship
Dr. Boeck focuses on trying to understand how the dynamic interaction of proteins and DNA determine the fundamental phenotypes and cell fates of organisms. While the information contained within the genome is static, the physical genome itself is a dynamic molecule, moving and changing in response to internal and external cues. These dynamics are dictated by the binding of proteins such as transcription factors and histones. Scientists are excellent at predicting where and when proteins bind to DNA. These predictions are, however, snapshots, do not reflect the true dynamics of the genome and are not good predictors of function. Dr. Boeck’s lab aims to examine the “moving picture” of DNA-protein interactions in an effort to improve our predictions of functional protein-DNA interactions. His lab focuses on the model organisms Saccharomyces Cerevisiae and Caenorhabditis Elegans.
Boeck ME, Huynh C, Gevirtzman L, Thompson OA, Wang G, Kasper DM, Reinke V, Hillier LW, Waterston RH. The time-resolved transcriptome of C. elegans. Genome Res. 2016 Aug 16
[Epub ahead of print]
Boeck ME, Boyle T, Bao Z, Murray J, Mericle B, Waterston R. Specific Roles for the GATA Transcription Factors end-1 and end-3 During C. elegans E-lineage Development Developmental Biology, 2011 Oct;358(2):345-55.
Arya et al. Comparative analysis of the transcriptome across distant species. Nature, 2014, Aug 28;512(7515):445-8
Murray JI, Boyle TJ, Preston E, Vafeados D, Mericle B, Weisdepp P, Zhao Z, Bao Z, Boeck M, Waterston RH. Multidimensional regulation of gene expression in the C. elegans embryo. Genome Res. 2012 Apr 16 Epub.
Murray JI, Boyle TJ, Preston E, Vafeados D, Mericle B, Weisdepp P, Zhao Z, Bao Z, Boeck M, Waterston RH. Automated analysis of embryonic gene expression with cellular resolution in C. elegans. Nat Methods. 2008 Aug;5(8):703-9. Epub 2008 Jun 29.
Feng W, Collingwood D, Boeck ME, Fox LA, Alvino GM, Fangman WL, Raghuraman MK, Brewer BJ. Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication. Nat Cell Biol. 2006 Feb;8(2):148-55. Epub 2006 Jan 22.