Professional Bio

Education

  • Postdoctoral Fellowship, Toxicology, University of California Davis

  • Ph.D., Environmental Health, Colorado State University

  • B.A., Environmental Studies, University of Colorado Boulder

Research & Scholarship

Research Interests

Dr. Streifel focuses on understanding how the nervous system is adversely affected by environmental exposures, particularly to metals. The metal Manganese (Mn) is an essential element, however it can also be a potent neurotoxin. Additionally, Mn has differential effects on juvenile and adult exposures, posing the important question of how early life exposure may impact or alter neurological function throughout the life span. Research projects focus on understanding how Manganese, among other exposures, lead to inflammation in the glial cells in the nervous system and how this could predispose neurological dysfunction.

Recent Publications

Hao Chen, Karin Streifel, Vikrant Singh, Dongren Yang, Linley Mangini, Heike Wulff, and Pamela Lein. (2016)     BDE-47 and BDE-49 inhibit axonal growth in primary rat hippocampal neuron-glia co-cultures via ryanodine receptor-dependent mechanisms. Toxicol Sci. PMID: 28003438
 
Joshua Harrill, Hao Chen, Karin Streifel, Dongren Yang, William Mundy, and Pamela Lein. (2015) Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons. Molecular brain 8(1): 10. PMID: 25757474

Karin Streifel, Albert Gonzales, Briana De Miranda, Rola Barhoumi, Scott Earley, and Ronald Tjalkens. (2014) Dopaminergic Neurotoxicants Cause Biphasic Inhibition of Purinergic Calcium Signaling in Astrocytes. PloS one. 9.11: e110996. PMID: 25365260

Mariana Stamou, Karin Streifel, Paula Goines, and Pamela Lein. (2013) Neuronal connectivity as a convergent target of gene-environment interactions that confer risk for Autism Spectrum Disorders. Neurotoxicol Teratol. 36: 3-16. PMID: 23269408 

Karin Streifel, James Miller, Rola Barhoumi, and Ronald Tjalkens. (2013) Manganese inhibits ATP-induced calcium entry through the transient receptor potential channel TRPC3 in astrocytes. Neurotoxicol. 34: 160-6. PMID: 23131343

Karin Streifel, Julie Moreno, Marie Legare, and Ronald Tjalkens. (2012) Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice. Toxicol Sci. 126(1):183-92. PMID: 22174044

Julie Moreno, Karin Streifel, Kelly Sullivan, William Hanneman, and Ronald Tjalkens. (2011) Manganese-induced NF-kB activation and nitrosative stress is decreased by estrogen in juvenile mice. Toxicol Sci. 122(1):121-33. PMID: 21512103

Julie Moreno, Karin Streifel, Kelly Sullivan, Marie Legare, and Ronald Tjalkens. (2009) Developmental exposure to manganese increases adult susceptibility to inflammatory activation of glial and neuronal protein nitration. Toxicol Sci. 112(2):405-15. PMID: 19812365

Julie Moreno, Claire Yeomans, Karin Streifel, Bryan Brattin, and Ronald Tjalkens. (2009) Age-dependent susceptibility to manganese-induced neurological dysfunction. Toxicol Sci. 112(2):394-404. PMID: 19812362


Awards & Recognition

Grants/Awards

• Individual National Research Service Award (NRSA) funded by the National Institute on Environmental Health and Safety (NIEHS), F32 ES024676, UC-Davis

• National Institute of Health (NIH) Postdoctoral Fellowship, Autism Research Training Program, UC-Davis M.I.N.D. Institute, NIMH - T32 MH073124, UC-Davis

• Travel Honorarium for the Interdisciplinary Development Conference in Developmental Disorders at the Gatlinburg Conference, Chicago, IL

• SOT Board of Publications best paper in Toxicological Sciences- Honorable Mention

• Graduate student travel award, 49th national SOT meeting, Salt Lake City, UT

• Environmental Health Sciences Outstanding Graduate Researcher Scholarship, CSU

• Dr. Reginald L. Gotchy Memorial Graduate Student Scholarship, CSU